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    Sensilia Laboratory is a French, family-owned and independent laboratory based in Gironde, France. Since 2019, we have been researching and manufacturing healthy, innovative wellness products.

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    Macro view of green-lipped mussels
    Ingredients

    Green-lipped mussel oil, a unique marine active ingredient

    The green-lipped mussel: an endemic treasure of New Zealand

    At the heart of New Zealand's pristine waters grows a remarkable marine ingredient: the green-lipped mussel. Recognisable by its characteristic emerald fringe, this endemic species has long been valued for its uniquely rich nutritional profile.

    New Zealand
    Map of New Zealand
    New Zealand
    Environment

    Sourced from the most pristine waters

    Green-lipped mussels are farmed in the Marlborough Sounds, a network of sheltered bays and fjords in the north of New Zealand’s South Island. These phytoplankton-rich waters provide ideal conditions for their natural development, with no artificial feed inputs.

    By continuously filtering water to feed, mussels naturally contribute to the balance of the marine ecosystem.

    Farming is tightly controlled through strict quotas and regulations to protect marine resources and biodiversity.

    Thanks to this responsible aquaculture model, New Zealand mussels today have one of the lowest carbon footprints of all animal protein sources.

    Heritage

    Where it all began

    The green-lipped mussel, Perna canaliculus, has been woven into New Zealand's history and culture for centuries. Known as kūtai, it was a vital food source for coastal Māori communities. Archaeological digs have uncovered extensive shell middens, confirming its importance to the country's earliest inhabitants.

    Nutrition

    A naturally exceptional lipid composition

    Green-lipped mussel oil is naturally rich in marine Omega-3s (EPA, DHA and ETA) and rare antioxidants. This unique composition makes it one of the most studied ingredients for supporting dogs' joints and preserving their mobility.

    Thanks to this natural richness in bioactive lipids, several clinical studies have demonstrated its effects on joint pain, lameness and mobility in dogs with osteoarthritis.

    Extracted using supercritical CO₂, this New Zealand green-lipped mussel oil is at the heart of the PERNIXOL® formulation.

    Macro view of freshly farmed green-lipped mussels
    Polyunsaturated fatty acids

    A world-unique, broad-spectrum Omega-3 profile

    18-20%

    EPA molecule (Eicosapentaenoic Acid)

    EPA (Eicosapentaenoic Acid)

    Helps reduce joint inflammation and relieve pain by acting on inflammatory mediators.

    13-16%

    DHA Omega-3 molecule

    DHA (Docosahexaenoic Acid)

    Supports cell membrane flexibility and helps protect joint tissues.

    3-4%

    SDA molecule

    SDA (Stearidonic Acid)

    As a precursor to active Omega-3 fatty acids, it supports the body’s natural production of EPA.

    0.45-1%

    ETA molecule

    ETA (Eicosatetraenoic Acid)

    A rare Omega-3 that strengthens overall anti-inflammatory action, with complementary activity to EPA.

    Antioxidants

    Rare and powerful antioxidants

    Xanthophyll carotenoids

    Xanthophyll molecule

    Natural antioxidant pigments that help protect cells from oxidative stress linked to inflammation.

    Furanic fatty acids

    F5 FFA molecule

    Rare marine lipids with powerful antioxidant and anti-inflammatory properties, recognised for helping protect cells from oxidative stress and supporting joint comfort.

    Mechanisms of action of green-lipped mussel oil

    PERNIXOL® oil dropper on a green background
    01

    Targeted anti-inflammatory action

    Regulation of inflammation

    Green-lipped mussel oil acts directly on the main biological pathways of joint inflammation responsible for pain and stiffness.

    • Inhibition of [REDACTED] of prostaglandins (PGE2) and leukotrienes (LTB4), major mediators of joint pain and inflammation
    • Modulation of COX and LOX enzymatic pathways involved in the inflammatory cascade
    • Reduction in the release of pro-inflammatory cytokines associated with chronic joint disorders
    • Contribution of furan fatty acids, green-lipped mussel-specific lipids whose anti-inflammatory activity exceeds that of EPA alone
    Macro view of green-lipped mussel oil
    02

    Bone and joint protection

    Joint protection

    Beyond pain relief, green-lipped mussel oil acts on the structural mechanisms of joint degradation involved in the progression of osteoarthritis.

    • Reduction in the activity of cells responsible for bone destruction (osteoclasts)
    • Decrease in the expression of key genes involved in joint degradation (NFATc1, MMP-9, cathepsin K)
    • Contribution to the preservation of subchondral bone, a central element in maintaining joint strength and function
    Macro view of an open green-lipped mussel
    03

    Complementary antioxidant activity

    Antioxidant power

    Green-lipped mussel oil also provides antioxidant activity that helps protect joint tissues from oxidative stress.

    • Neutralisation of free radicals involved in joint oxidative stress
    • Overall antioxidant activity measured at approximately 62%, comparable to that of vitamin C under experimental conditions
    • Protection of cell membranes rich in polyunsaturated lipids, particularly sensitive to oxidation
    • Key role of specific lipids and natural antioxidants present in green-lipped mussel

    Veterinary studies

    Dog in the mountains
    Green lipped mussel oil
    Bone

    Slowing bone degradation

    Slowing bone degradation

    Experimental study evaluating the effect of green lipped mussel lipids on the differentiation of cells responsible for bone resorption (osteoclasts).

    Experimental study evaluating the effect of green lipped mussel lipids on the differentiation of cells responsible for bone resorption (osteoclasts).

    Siriarchavatana P, Kruger MC, Miller MR, Tian H, Wolber FM. Non-polar lipid from greenshell mussel (Perna canaliculus) inhibits osteoclast differentiation. Bone Rep. 2021 Sep 24;15:101132. doi: 10.1016/j.bonr.2021.101132. PMID: 34632003; PMCID: PMC8493498.

    Rottweiler dog taking green lipped mussel oil
    Green lipped mussel oil
    Comparison

    Superior efficacy compared to fish oils

    Superior efficacy compared to fish oils

    Prospective, randomized comparative clinical study conducted in 66 dogs with shoulder and/or hip osteoarthritis.

    Prospective, randomized comparative clinical study conducted in 66 dogs with shoulder and/or hip osteoarthritis.

    Mongkhon, Natwadee & Nganvongpanit, Korakot & Kongtaweelert, Prachya. (2015). Effect of PCSO-524 on OA Biomarkers and Weight-Bearing Properties in Canine Shoulder and Coxofemeral Osteoarthritis. Thai Journal of Veterinary Medicine. 45. 157-165. 10.56808/2985-1130.2632.

    Dog filmed by drone
    Green lipped mussel oil
    Muscle disorders

    Benefits in athletic dogs

    Benefits in athletic dogs

    Randomized clinical study conducted in 27 active herding dogs presenting musculoskeletal disorders.

    Randomized clinical study conducted in 27 active herding dogs presenting musculoskeletal disorders.

    Cave N., Bolton S., Cogger N. (2024). A pilot study to detect the effects of a green-lipped mussel (Perna canaliculus) nutraceutical on working farm dogs with musculoskeletal abnormalities using accelerometry. New Zealand Veterinary Journal, 72(6), 323–333.

    Dogs of different breeds playing together
    Green lipped mussel oil
    Osteoarthritis

    Green lipped mussel oil + NSAIDs in arthritic dogs

    Green lipped mussel oil + NSAIDs in arthritic dogs

    Prospective, randomized, double-blind clinical study conducted in dogs with osteoarthritis to compare the effect of green lipped mussel oil, firocoxib, and their combination on pain and limb loading.

    Prospective, randomized, double-blind clinical study conducted in dogs with osteoarthritis to compare the effect of green lipped mussel oil, firocoxib, and their combination on pain and limb loading.

    Vijarnsorn M, Kwananocha I, Kashemsant N, Jarudecha T, Lekcharoensuk C, Beale B, Peirone B, Lascelles BDX. The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis. BMC Vet Res. 2019 Oct 17;15(1):349. doi: 10.1186/s12917-019-2110-7. Erratum in: BMC Vet Res. 2020 Dec 16;16(1):486. doi: 10.1186/s12917-020-02713-9. PMID: 31623621; PMCID: PMC6798752.

    A dog running
    Green lipped mussel oil
    Osteoarthritis

    Clinical improvement in pain and mobility

    Clinical improvement in pain and mobility

    Clinical study conducted on 84 dogs with multi-site osteoarthritis or degenerative spinal disorders.

    Clinical study conducted on 84 dogs with multi-site osteoarthritis or degenerative spinal disorders.

    Mongkon N., Soontornvipart K. (2012). Preliminary study of the clinical outcome of using PCSO-524 polyunsaturated fatty acid compound in the treatment of canine osteoarthritis and degenerative spinal diseases. Thai Journal of Veterinary Medicine, 42(3), 311–320.

    Senior dog looking out the window
    Omega-3
    Osteoarthritis

    Reduction of canine osteoarthritis

    Reduction of canine osteoarthritis

    Prospective, randomized, double-blind, placebo-controlled clinical study conducted in dogs with osteoarthritis to evaluate the combined effect of EPA and DHA on clinical signs and blood inflammation markers.

    Prospective, randomized, double-blind, placebo-controlled clinical study conducted in dogs with osteoarthritis to evaluate the combined effect of EPA and DHA on clinical signs and blood inflammation markers.

    Mehler SJ, May LR, King C, Harris WS, Shah Z. A prospective, randomized, double blind, placebo-controlled evaluation of the effects of eicosapentaenoic acid and docosahexaenoic acid on the clinical signs and erythrocyte membrane polyunsaturated fatty acid concentrations in dogs with osteoarthritis. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:1-7. doi: 10.1016/j.plefa.2016.03.015. Epub 2016 Mar 30. PMID: 27269707.

    A dog walking in water
    DHA
    Inflammation

    Regulation of inflammation

    Regulation of inflammation

    Several experimental studies have evaluated the impact of DHA from microalgae on inflammatory mechanisms and pain, particularly in pro-inflammatory nutritional contexts and acute pain.

    Several experimental studies have evaluated the impact of DHA from microalgae on inflammatory mechanisms and pain, particularly in pro-inflammatory nutritional contexts and acute pain.

    Velebný, J., Kopecký, J., Jeníček, V., et al. (2015). Schizochytrium microalga oil reduces body weight, glycaemia and inflammatory markers in rats fed a high-fat diet. Journal of Animal Physiology and Animal Nutrition, 99(4), 711–721. https://doi.org/10.1111/jpn.12434 Zhang, L., Terrando, N., Xu, Z.-Z., Bang, S., Jordt, S.-E., Maixner, W., Serhan, C. N., & Ji, R.-R. (2018). Distinct analgesic actions of DHA and DHA-derived specialized pro-resolving mediators on post-operative pain after bone fracture in mice. Frontiers in Pharmacology, 9, 412. https://doi.org/10.3389/fphar.2018.00412

    Dog walking in mud
    DHA
    Cartilage

    Cartilage protection

    Cartilage protection

    Experimental study conducted on an induced osteoarthritis model (ACLT) to evaluate the impact of DHA on the progression of joint degradation.

    Experimental study conducted on an induced osteoarthritis model (ACLT) to evaluate the impact of DHA on the progression of joint degradation.

    Xie, Y., Zhou, W., Zhong, Z., Yu, H., Zhang, P., & Shen, H. (2019). Docosahexaenoic acid inhibits bone remodeling and vessel formation in the osteochondral unit in a rat model of osteoarthritis. Biomedicine & Pharmacotherapy, 118, 109309. https://doi.org/10.1016/j.biopha.2019.109309

    PERNIXOL® range

    PERNIXOL® is rich in New Zealand green-lipped mussel oil extracted using supercritical CO₂ to support dogs' joints.

    PERNIXOL®210

    PERNIXOL®210

    Dogs weighing 10 to 20 kg

    €33.53 - €47.90

    PERNIXOL®420

    PERNIXOL®420

    Dogs weighing 20 kg or more

    €38.43 - €54.90

    PERNIXOL®70

    PERNIXOL®70

    Dogs under 10 kg

    €27.93 - €39.90

    Aerial view of an ocean shoreline

    High safety profile

    Green-lipped mussel oil has an excellent tolerance profile, suitable for daily use, including long term.

    Excellent digestive tolerance

    Green-lipped mussel oil is very well tolerated and readily digested by dogs, including sensitive or senior dogs. It can be administered daily, with no reported digestive discomfort.

    No contraindications

    Green-lipped mussel oil can be used:

    • alongside other functional foods,
    • in combination with veterinary treatments, with no known negative interactions

    Suitable for all dogs

    • For dogs with occasional or chronic joint disorders (osteoarthritis, dysplasia, lameness, bone spurs, luxation)
    • For genetically predisposed dogs including puppies (Labrador, Golden Retriever, German Shepherd, Rottweiler, Bulldog, Dachshund…)
    • For active, athletic or hard-working dogs (working dogs, agility, canicross)
    • For senior dogs

    Safe for long-term use

    Available scientific data show an absence of adverse effects, even with prolonged use.


    Green-lipped mussel oil has no harmful effect on the dog's general health.

    Quality & Traceability

    Uncompromising standards and purity.

    Certifications

    Food-grade quality

    • FSSC 22000 certification
    • HACCP standards
    • Non-GMO

    Controls

    Rigorous testing

    • Systematic independent testing
    • Omega-3 content control
    • Verified absence of heavy metals, dioxins, PCBs and pesticides
    • Strict microbiological monitoring
    • Ongoing monitoring through the Marlborough Shellfish Quality Programme (MSQP)

    Sustainability

    Certified sustainable source

    • Certified aquaculture through the A+ New Zealand Sustainable Aquaculture programme
    • Low carbon footprint
    • Mussel reef restoration

    Extraction

    Gentle extraction

    • Supercritical CO₂ extraction
    • Clean method that preserves the active compounds of the green-lipped mussel
    • Solvent-free
    FAQ

    Frequently asked questions

    Find the answer to your questions

    All FAQs

    Awaken your curiosity

    The Sensilia Journal brings together scientific content, practical guides and expert advice to help you better understand your dog's health and nutrition.

    New Zealand green-lipped mussel with water droplets highlighting the purity of this rare, protected natural ingredient
    Natural Ingredients
    Moule verte

    Green-lipped mussel for osteoarthritis: a natural joint support for dogs

    Green-lipped mussel for osteoarthritis: a natural joint support for dogs

    Green-lipped mussel for dogs with osteoarthritis: evidence-backed benefits, oil vs powder, dosing and how long to supplement for better mobility and joint comfort.

    Green-lipped mussel for dogs with osteoarthritis: evidence-backed benefits, oil vs powder, dosing and how long to supplement for better mobility and joint comfort.

    Read More
    Close-up of open New Zealand green-lipped mussels with orange flesh and green and blue pearlescent highlights on a dark, wet background, illustrating their role in supporting joint mobility.
    Clinical Studies
    Green-lipped mussel oil

    Veterinary studies: green lipped mussel oil for dog osteoarthritis

    Veterinary studies: green lipped mussel oil for dog osteoarthritis

    Green-lipped mussel oil may help dogs move more comfortably and support dogs with osteoarthritis, according to recent veterinary studies.

    Green-lipped mussel oil may help dogs move more comfortably and support dogs with osteoarthritis, according to recent veterinary studies.

    Read More
    New Zealand green-lipped mussels harvested at sea before oil extraction for a canine joint health supplement
    Natural Ingredients
    Moule verte

    New Zealand Green-Lipped Mussel: Origin, Farming & Omega-3 Oil

    New Zealand Green-Lipped Mussel: Origin, Farming & Omega-3 Oil

    Learn where New Zealand green-lipped mussels come from, how they are farmed sustainably and how their omega-3-rich oil is extracted.

    Learn where New Zealand green-lipped mussels come from, how they are farmed sustainably and how their omega-3-rich oil is extracted.

    Read More
    Macro comparison between green lipped mussel powder and green lipped mussel oil, illustrating their differences in purity and Omega-3 concentration.
    Buying Guides
    Green lipped mussel

    Green Lipped Mussel Oil vs Powder: What to Choose for Canine Osteoarthritis?

    Green Lipped Mussel Oil vs Powder: What to Choose for Canine Osteoarthritis?

    Green-lipped mussel oil or powder? Discover their differences and why oil, with its higher omega-3 concentration, is the most effective form for supporting your dog's mobility.

    Green-lipped mussel oil or powder? Discover their differences and why oil, with its higher omega-3 concentration, is the most effective form for supporting your dog's mobility.

    Read More